We are aware of no case reports of serotonin syndrome caused by phentermine alone.
Does phentermine affect serotonin?
Phentermine is a sympathomimetic amine that works on the central nervous system to suppress appetite. It has been shown to stimulate the release of norepinephrine in the hypothalamus, with no effects on serotonin. It is dosed up to 37.5 mg/day for short-term obesity treatment.
Which drugs cause serotonin syndrome?
The drugs and supplements that could potentially cause serotonin syndrome include: Selective serotonin reuptake inhibitors (SSRIs), antidepressants such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine, paroxetine (Paxil, Pexeva, Brisdelle) and sertraline (Zoloft)
What are the bad side effects of phentermine?
Dizziness, dry mouth, difficulty sleeping, irritability, nausea, vomiting, diarrhea, or constipation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. This medication may raise your blood pressure.
Does phentermine make anxiety worse?
For people with agitation: This drug may cause restlessness and anxiety and may make your agitation worse. You shouldn’t take phentermine if you’re agitated.
What happens when you stop taking phentermine?
Abrupt cessation of long-term phentermine therapy does not induce amphetamine-like withdrawal. Long-term phentermine therapy does not induce phentermine cravings. Symptoms observed after abrupt phentermine cessation represent loss of therapeutic effect and are not withdrawal.
Does phentermine affect your brain?
Phentermine increases release of neurotransmitters which simulate metabolism and suppress appetite. Phentermine is a “sympathomimetic” because it simulates the release and inhibition of certain neurotransmitters in your brain. Essentially it tricks your mind into feeling full!
How do you fix serotonin syndrome?
Depending on your symptoms, you may receive the following treatments:
- Muscle relaxants. …
- Serotonin-production blocking agents. …
- Oxygen and intravenous (IV) fluids. …
- Drugs that control heart rate and blood pressure. …
- A breathing tube and machine and medication to paralyze your muscles.
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How quickly does serotonin syndrome occur?
Most cases of serotonin syndrome start within 24 hours after starting or increasing a serotonergic medication and the majority of those start within six hours.
Does Benadryl help serotonin syndrome?
Serotonin syndrome should not be treated at home with over-the-counter medications. The prescription antihistamine, cyproheptadine, works as an antidote for excessive serotonin, but other antihistamines, like Benadryl (diphenhydramine), work differently.
Can phentermine cause long term damage?
Long-term use of Adipex-P may cause physical and psychological dependence. A withdrawal reaction consisting of excessive drowsiness, fatigue, tremors and depression may occur after prolonged use.
Do you gain weight after you stop taking phentermine?
Without making the proper changes, it is likely that you’ll gain back the weight you lost — and possibly more — once you stop taking phentermine. A comprehensive lifestyle change includes: A reduced-calorie diet: If you have excess weight to lose, eat 300–500 fewer calories per day.
What happens if you take too much phentermine?
An overdose of phentermine can be fatal.
Overdose symptoms may include confusion, panic, hallucinations, extreme restlessness, nausea, vomiting, diarrhea, stomach cramps, feeling tired or depressed, irregular heartbeats, weak pulse, seizure, or slow breathing (breathing may stop).
Can phentermine make you crazy?
Phentermine is a sympathomimetic amine, like amphetamine, which is one of the most often prescribed drugs for weight loss. Although exact mechanism of phentermine causing psychosis is still not clear, numerous reports already showed that phentermine can induce psychosis.
How long does phentermine withdrawal last?
It is recommended to taper Adipex use rather than immediately stopping. Adipex will generally be out of your system about two days after the last time you take it.
Does phentermine insomnia go away?
This side effect will help remind you to increase your water intake. Insomnia: Because it is a stimulant, phentermine will most likely keep you awake if you take it too late in the day. This side effect also decreases in most patients after they have been on the medication for several weeks.