Fluoxetine has been noted to cause asymptomatic liver enzyme elevations in about 0.5% of patients. The safety of fluoxetine-an update. Recently, fluoxetine-associated chronic hepatitis was reported.
Is Prozac safe for the liver?
Introduction. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) widely used as an antidepressant. Fluoxetine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
Can antidepressants cause liver damage?
Some antidepressants can damage your liver over time, including monoamine oxidase (MAO) inhibitors, tricyclic or tetracyclic antidepressants, bupropion, duloxetine and agomelatine. Antidepressant drugs with a lower risk of liver damage include citalopram, escitalopram, paroxetine and fluvoxamine.
Can Prozac cause high liver enzymes?
Fluoxetine is associated with an asymptomatic increase in liver enzymes in 0.5% of the cases but is rarely associated with either FHF or SJS.
Can fluoxetine cause fatty liver?
Fatty Liver is Linked to Maternal Use of the SSRI Antidepressant Fluoxetine. Adult offspring of mothers who used fluoxetine, a common antidepressant, during pregnancy were more likely to develop a fatty liver, a new animal study has found.
Does Prozac affect your kidneys?
Of these, five patients undergoing hemodialysis and five patients with normal renal function experienced moderate to marked improvement in their depression. Side effects were equal and minor in both groups, indicating that fluoxetine is safe in patients with renal impairment.
What supplements are bad for the liver?
In fact, some common herbs could cause toxic liver disease. Watch out for supplements that contain aloe vera, black cohosh, cascara, chaparral, comfrey, ephedra, or kava. Chemicals and solvents. Some workplace chemicals can harm your liver.
Does taking drugs affect your liver?
Chronic use of some drugs, such as heroin, inhalants, and steroids (appearance- and performance-enhancing drugs), may lead to significant damage to the liver. This damage can be worse when these drugs are combined with alcohol or other drugs.
Which antidepressant is easiest on the liver?
The antidepressants that seem to have the least potential for hepatotoxicity are citalopram, escitalopram, paroxetine, and fluvoxamine. Cross-toxicity has been described, mainly for tricyclic and tetracyclic antidepressants.
What medications should I avoid with a fatty liver?
Medications commonly implicated in causing fatty liver include corticosteroids, antidepressant and antipsychotic medications and, most commonly, tamoxifen.
Are you supposed to take Prozac at the same time every day?
Take fluoxetine once a day. You can take it with or without food. You can take fluoxetine at any time, as long as you stick to the same time every day. If you have trouble sleeping, it’s best to take it in the morning.
What do elevated liver enzymes mean?
Elevated liver enzymes often indicate inflammation or damage to cells in the liver. Inflamed or injured liver cells leak higher than normal amounts of certain chemicals, including liver enzymes, into the bloodstream, elevating liver enzymes on blood tests.
How is fluoxetine excreted from the body?
The primary route of elimination appears to be hepatic metabolism to inactive metabolites excreted by the kidney. Clinical issues related to metabolism/elimination — The complexity of the metabolism of fluoxetine has several consequences that may potentially affect fluoxetine’s clinical use.
What are the side effects of fluoxetine?
Fluoxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- difficulty falling asleep or staying asleep.
- dry mouth.
Can you stay on Prozac for life?
Sharing the Research: When patients ask about the long-term use of antidepressant medication, the truth is there really isn’t any. Prozac has been around since the 1980s but published long-term studies of antidepressant medications range from 3 to 15 years.
Is Propecia bad for your liver?
Finasteride is a 5-alpha reductase inhibitor used to treat symptoms of benign prostatic hypertrophy and male pattern baldness. Finasteride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of clinically apparent, acute liver injury.