Conclusion: According to our findings, Trazodone decreases the concentration of testosterone level and the number of spermatogenic cells and increases FSH and LH levels at high doses. Also, it can probably weaken the function of reproduction activity.
Do antidepressants affect hormones?
Acute administration of SSRIs increases the secretion of several hormones, but chronic treatment with SSRIs does not alter basal blood levels of hormones. However, adaptive changes are induced by long-term treatment with SSRIs in serotonergic, noradrenergic and peptidergic neural function.
Does Trazodone affect testosterone?
Additionally, serum FSH, LH, and testosterone levels were elevated in the trazodone-administered groups. Increased MDA levels were the signs of enhanced oxidative stress after trazodone administration in testis tissues.
What are the negative side effects of trazodone?
Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the mouth, stuffy nose, constipation, or change in sexual interest/ability may occur.
What are the most common side effects of trazodone?
The more common side effects of trazodone can include:
- stuffy nose.
- weight loss.
- blurred vision.
Can antidepressants affect memory?
Tranquilizers, antidepressants, some blood pressure drugs, and other medications can affect memory, usually by causing sedation or confusion. That can make it difficult to pay close attention to new things. Talk to your doctor or pharmacist if you suspect that a new medication is taking the edge off your memory.
Can antidepressants increase estrogen?
Although the mechanisms of disruption were all different, they all resulted in decreased testosterone levels, some due to effects on CYP17, some earlier in the pathway. Furthermore, all SSRIs relatively increased the estrogen/androgen ratio, indicating stimulating effects on the aromatase.
Does Trazodone affect you sexually?
SSRIs = selective serotonin reuptake inhibitors.
Effects on Libido of Various Antidepressants and Other Medications.
|Medication||Libido effect||Other sexual effects|
|Trazodone (Desyrel)||Increase||Priapism (rare)|
|Nefazodone (Serzone)||No change||None|
Does Trazodone cause weight gain?
Trazodone can make you feel more or less hungry than usual, so you may lose or gain weight when you start taking it. If you start to have problems with your weight while taking trazodone, talk to your doctor or pharmacist.
What are the long term side effects of trazodone?
What Are Side Effects Associated with Using Trazodone?
- blurred vision.
- dry mouth.
- headache or mild headache.
How long does it take Trazodone to kick in for sleep?
Patients who take the drug for a sleep disorder can experience the sedative effects within 30 minutes, depending on the type used. Patients who take the drug as an antidepressant may not notice symptom relief for one to two weeks, and it may take up to four weeks to experience the full benefits.
Does Trazodone affect memory?
Trazodone produced small but significant impairments of short-term memory, verbal learning, equilibrium, and arm muscle endurance across time points.
Is it OK to take 100mg of trazodone for sleep?
Trazodone is most often prescribed at doses between 25mg to 100mg as a sleep aid. However, studies show lower dosages of trazodone are effective and may cause less daytime sleepiness and fewer side effects because the drug is short acting.
Can Trazodone be stopped suddenly?
Continue to take trazodone even if you feel well. Do not stop taking trazodone without talking to your doctor. If you suddenly stop taking trazodone, you may experience withdrawal symptoms such as anxiety, agitation, or difficulty falling asleep or staying asleep. Your doctor will probably decrease your dose gradually.
Is trazodone like Xanax?
Xanax is similar to trazodone in that it may cause side effects such as feeling tired and drowsy. When this occurs during the day, it can affect your day-to-day activities. However, unlike trazodone, Xanax and other benzodiazepine drugs can be addictive, even if you’ve been using them as directed.
What should I eat with Trazodone?
To lessen stomach upset and to reduce dizziness and lightheadedness, take the regular tablet with or shortly after a meal or light snack. Take the extended-release tablet at the same time each day, preferably at bedtime, without food.