The exact cause of glucose dysregulation by olanzapine is not clear. It has been hypothesized that 5-HT1 antagonism may decrease the responsiveness of the pancreatic beta cells, thus reducing the secretion of insulin and causing hyperglycemia.
Why do antipsychotics cause diabetes?
Antipsychotics likely increase the risk of diabetes through weight gain and directly by adversely affecting insulin sensitivity and secretion.
Can Zyprexa cause diabetes?
One in six patients who take Zyprexa will gain more than 33 pounds after two years of use, the label says. Weight gain and high blood sugar are risk factors for diabetes, although Lilly says there has been no proof that Zyprexa causes diabetes more than its competitors do.
Can psych meds cause diabetes?
There is an increased risk of diabetes in patients with schizophrenia and this risk is elevated by some antipsychotic medications. The risk is greater with the atypical drugs clozapine and olanzapine and the low potency conventional antipsychotics than with risperidone or high potency conventional drugs.
Does olanzapine cause insulin resistance?
Recent clinical studies and reviews have indicated that chronic olanzapine treatment is often associated with severe metabolic side effects, such as obesity, dyslipidemia and insulin resistance (IR), which increase the risk of type 2 diabetes, cardiovascular disease and noncompliance in schizophrenia patients13,14,15, …
Can antipsychotics cause suicidal thoughts?
Antipsychotics can act stimulatingly upon predictors of suicidal behavior, that is, pro-suicidal in an indirect way through side effects they cause indirect pro-suicidal neurological and consecutive psychological impact, as it is called.
Do antipsychotics cause insulin resistance?
Researchers have concluded that insulin resistance and metabolic syndrome can manifest in schizophrenia before and after the initiation of antipsychotics.
How bad is olanzapine?
Olanzapine raises the risk of death in seniors (ages 65 years or older) with dementia-related psychosis. Most of these deaths are caused by heart problems such as heart failure, or infectious conditions such as pneumonia. For people with seizures: Olanzapine can cause seizures.
Does olanzapine raise blood sugar?
Recently, a flurry of reports have stated that olanzapine is associated with high blood sugar levels in new onset or pre-existing diabetes mellitus and ketoacidosis,[1–4] which may be reversible after discontinuation of olanzapine. The exact cause of glucose dysregulation by olanzapine is not clear.
What happens when you take Zyprexa?
Drowsiness, dizziness, lightheadedness, stomach upset, dry mouth, constipation, increased appetite, or weight gain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Dizziness and lightheadedness can increase the risk of falling.
Does diabetes medication cause weight gain?
Gaining Weight on Medication. A number of widely prescribed diabetes medications have been linked with increased weight gain. It can be hugely frustrating when medicines which we take to improve our blood glucose levels and diabetes control make it harder for us to manage our weight.
What happens when you take antipsychotics?
Side-effects of typical antipsychotics vary depending on the drug and may include drowsiness, agitation, dry mouth, constipation, blurred vision, emotional blunting, dizziness, stuffy nose, weight gain, breast tenderness, liquid discharge from breasts, missed periods, muscle stiffness or spasms.
Can haloperidol cause diabetes?
Of 5,981 veterans who took Zyprexa, 200, or 3.34 percent, developed diabetes, compared with 170, or 2.43 percent, of 7,009 veterans taking Haldol or another older medication.
What are the long term side effects of olanzapine?
The biggest disadvantages of Zyprexa are the potential long-term side effects, which can include tardive dyskinesia, increased blood sugar, and weight gain.
Can olanzapine cause liver damage?
Hepatotoxicity. Liver test abnormalities have been reported to occur in 10% to 50% of patients on long term therapy with olanzapine. These abnormalities are usually mild, asymptomatic and transient, and can reverse even with continuation of medication.
Does Zyprexa cause metabolic syndrome?
Olanzapine is an atypical antipsychotic drug used to treat schizophrenia. Some of the adverse effects related to its use are obesity, hyperlipidemia, type 2 diabetes and hypertension, which may result in development of metabolic syndrome.