Conclusion: This study demonstrates that aripiprazole is equally efficacious as olanzapine in the treatment of schizophrenia. Aripiprazole has a more benign side effect profile (weight gain, blood sugar level, lipid profile) as compared to olanzapine in the short-term treatment of schizophrenia.
Is olanzapine more effective than aripiprazole?
Earlier, Fleischhacker et al30 in their study comparing the efficacy and tolerability of aripiprazole with olanzapine in patients with schizophrenia found that olanzapine had a statistically significant efficacy advantage over aripiprazole, with more reduction in Positive and Negative Syndrome Scale (PANSS) total score …
What is the strongest anti psychotic drug?
Clozapine, which has the strongest antipsychotic effect, can cause neutropenia.
Is olanzapine the best antipsychotic?
Olanzapine was among 4 antipsychotics (which also included clozapine, amisulpride, and risperidone) determined to be significantly more effective than other choices in the acute treatment of schizophrenia, based on improvements in PANSS or BPRS scores, and among 5 antipsychotics (also including amisulpride, clozapine, …
Which antipsychotic has the least side effects?
Aripiprazole is similar in effectiveness to risperidone and somewhat better than ziprasidone. Aripiprazole had less side- effects than olanzapine and risperidone (such as weight gain, sleepiness, heart problems, shaking and increased cholesterol levels).
What is the weakest antipsychotic?
Of the atypical antipsychotics, risperidone is the weakest in terms of atypicality criteria. Although early clinical studies with risperidone indicated that the incidence of EPS is not greater than that seen with placebo, this may not be the case.
Is olanzapine a good drug?
Olanzapine has an average rating of 6.0 out of 10 from a total of 717 ratings on Drugs.com. 47% of those users who reviewed Olanzapine reported a positive effect, while 30% reported a negative effect.
Do antipsychotics ruin your brain?
Research on other kinds of structural brain changes caused by antipsychotic drugs has been negative to date. There is no evidence, for example, that antipsychotic drugs cause any loss of neurons or neurofibrillary tangles such as are found in Alzheimer’s disease.
Do antipsychotics change the brain permanently?
Meyer-Lindberg himself published a study last year showing that antipsychotics cause quickly reversible changes in brain volume that do not reflect permanent loss of neurons (see “Antipsychotic deflates the brain”).
What does aripiprazole do to the brain?
Aripiprazole is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Aripiprazole rebalances dopamine and serotonin to improve thinking, mood, and behavior.
Does OLANZapine calm you down?
Olanzapine gave me that opportunity in a way; it gave me peace for the first time in months. It didn’t stop the pain or the anxiety, but it gave me the ability to rest, sleep, and relax.
How does Olanzapine make you feel?
These can include feeling very thirsty, needing to urinate often, having an increased appetite, or feeling weak. If you have these symptoms, check your fasting blood sugar level and call your doctor. For people with heart problems: Olanzapine can cause a sudden drop in blood pressure.
Does olanzapine change your personality?
Occasionally, it can have the opposite effect and provoke serious paradoxical reactions in a small subgroup of people, causing unusual changes in personality, thoughts, or behavior; hallucinations and excessive thoughts about suicide have also been linked to olanzapine use.
What is an alternative to olanzapine?
It has been suggested that risperidone is associated with a lower propensity for abnormalities in glucose‐insulin homeostasis than clozapine4, 8 and olanzapine. This case suggests that risperidone may be an alternative for patients with hyperglycemia, which is associated with atypical antipsychotic drugs.
What is the safest antipsychotic in pregnancy?
There is no good evidence that any one antipsychotic is the safest to use in pregnancy. However, one large study, which found no increased risk of birth defects for antipsychotics in general, did show a small increased risk with Risperidone4.
What is the newest antipsychotic drug?
Paliperidone, iloperidone, asenapine, and lurasidone are the newest oral atypical antipsychotic medications to be introduced since the approval of aripiprazole in 2002.