Quick Answer: Is Lexapro a CYP3A4 inhibitor?

Although escitalopram and its metabolites are weak to negligible inhibitors of the cytochrome P450 (CYP) 3A4 isozyme and are therefore unlikely to affect plasma concentrations of ritonavir (a CYP3A4 substrate and prototype CYP3A4 inhibitor), ritonavir may potentially affect plasma concentrations of escitalopram, as …

What drugs are CYP3A4 inhibitors?

Potent inhibitors of CYP3A4 include clarithromycin, erythromycin, diltiazem, itraconazole, ketoconazole, ritonavir, verapamil, goldenseal and grapefruit. Inducers of CYP3A4 include phenobarbital, phenytoin, rifampicin, St. John’s Wort and glucocorticoids.

How is Lexapro metabolized?


Escitalopram is metabolized in humans by 3 cytochrome P450 (CYP) hepatic enzymes that each offer relatively comparable contributions to intrinsic clearance of the drug: CYP2C19 (36%), CYP2D6 (30%), and CYP3A4 (34%).

What enzyme metabolizes Lexapro?

Aims: The antidepressant escitalopram (S-CIT) is metabolized by the cytochrome-P450 (CYP) enzymes CYP 2D6, 2C19 and 3A4.

What are strong CYP3A4 inhibitors?

Strong inhibitors Moderate inhibitors
CYP3A4 clarithromycin(h), idelalisib, nefazodone, nelfinavir(h)

Is grapefruit a CYP450 inhibitor or inducer?

At times, these CYP450 inducers and inhibitors are commonly ingested items such as grapefruit juice and tobacco. In the case of grapefruit juice, there are numerous medications known to interact with grapefruit juice including statins, antiarrhythmic agents, immunosuppressive agents, and calcium channel blockers.

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What drugs are inhibitors?

Examples of ACE inhibitors include:

  • Capoten (captopril)
  • Vasotec (enalapril)
  • Prinivil, Zestril (lisinopril)
  • Lotensin (benazepril)
  • Monopril (fosinopril)
  • Altace (ramipril)
  • Accupril (quinapril)
  • Aceon (perindopril)

4 сент. 2019 г.

What can you not mix with Lexapro?

Drug interactions of Lexapro include monoamine oxidase inhibitors (MAOIs), tryptophan, St. John’s wort, meperidine, lithium, triptans, tramadol, warfarin, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and other drugs that cause bleeding.

Can I stay on Lexapro forever?

Continue taking antidepressant medicine even when you start to feel better. Although it may be tempting to stop medication as your mood lifts, continue taking it for as long as your doctor recommends. Most doctors advise patients to take antidepressants for six months to a year after they no longer feel depressed.

Can Lexapro damage your liver?

Although thought to be generally safe and with minimal drug-drug interactions, clinicians should be aware of the possibility of escitalopram-induced liver injury when initiating depressed patients on antidepressant treatment. This requires extra vigilance as most patients may remain asymptomatic.

Is 30 mg Lexapro too much?

Lexapro is approved for daily doses of not more than 20 mg. In practice, however, doctors have prescribed up to 50 mg for patients showing no response to lower dosages.

Can you stay on 5mg of Lexapro?

Social anxiety disorder The normally recommended dose of Lexapro is 10 mg taken as one daily dose. Your doctor can either decrease your dose to 5 mg per day or increase the dose to a maximum of 20 mg per day, depending on how you respond to the medicine.

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Is Lexapro safe for kidneys?

10 mg/day is the recommended dose for most elderly patients and patients with hepatic impairment. No dosage adjustment is necessary for patients with mild or moderate renal impairment. Lexapro should be used with caution in patients with severe renal impairment.

What inhibits cyp450?

Cytochrome P450 enzymes can be inhibited or induced by drugs, resulting in clinically significant drug-drug interactions that can cause unanticipated adverse reactions or therapeutic failures. Interactions with warfarin, antidepressants, antiepileptic drugs, and statins often involve the cytochrome P450 enzymes.

Is grapefruit juice a CYP3A4 inhibitor?

Grapefruit juice inhibits CYP3A4, which is involved in the metabolism of quinine.

What are P gp inhibitors?

P-glycoprotein is an important mediator of drug-drug interactions. The pharmacokinetics of a drug may be altered when co-administered with compounds which inhibit or induce P-glycoprotein. Inhibitors include clarithromycin, erythromycin, ritonavir and verapamil. Inducers include rifampicin and St John’s wort.