Trazodone is rapidly absorbed in the gastrointestinal tract after oral administration, with a bioavailability ranging from 63-91% 9 and an AUC0−t of 18193.0 ng·h/mL.
Where is trazodone metabolized?
Trazodone is extensively metabolized by the liver, mainly via the cytochrome P450 system (CYP3A4), and hepatotoxicity may be mediated by toxic intermediates of its metabolism.
Is Trazodone a drug AZ?
What Is Trazodone, Anyway? Trazodone was first approved as an antidepressant by the Food and Drug Administration in 1981. Although doctors can legally prescribe trazodone (and all drugs, for that matter) for any reason, even if it’s not FDA-approved for that use, the drug has never been approved to treat insomnia.
How is trazodone excreted?
The drug is extensively metabolized in the liver. Trazodone should be used with caution in patients with renal impairment. While less than 1% of an oral dose is excreted unchanged in the urine; trazodone’s active metabolite and other metabolites are excreted primarily in the urine.
Is Trazodone a central nervous system depressant?
Trazodone can also cause some effects on the central nervous system, as a depressant. While a trazodone high isn’t a reported effect with this drug, if you mix it with certain other substances, it can amplify the effects of those.
Is trazodone hard on the liver?
Trazodone may cause alteration of liver enzyme levels at normal doses, but elevations are usually modest and usually do not require dose modification or discontinuation. Rare instances of ALF and death from trazodone have been described.
Does Trazodone make you gain weight?
Trazodone can make you feel more or less hungry than usual, so you may lose or gain weight when you start taking it. If you start to have problems with your weight while taking trazodone, talk to your doctor or pharmacist.
How long do you sleep on trazodone?
The 3 to 6 hour half-life of trazodone makes it most suitable for treating sleep onset insomnia or maintenance insomnia.
Is trazodone like Xanax?
Xanax is similar to trazodone in that it may cause side effects such as feeling tired and drowsy. When this occurs during the day, it can affect your day-to-day activities. However, unlike trazodone, Xanax and other benzodiazepine drugs can be addictive, even if you’ve been using them as directed.
What medications should not be taken with Trazodone?
Drugs you should not use with trazodone
Examples of these drugs include: Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, tranylcypromine, or selegiline. You shouldn’t take trazodone with MAOIs or within 14 days of taking them. Taking these drugs together raises your risk for serotonin syndrome.
Does Trazodone make you sleepy the next day?
Trazodone usage can cause a decrease in sodium levels in the body, a disruption of the nervous system or serotonin syndrome. The most common side effects include: Drowsiness (including feeling groggy the next day) Dizziness (including an increased risk of fainting/falling)
How long does trazodone stay in your system?
Factors that Affect How Long Trazodone Stays in Your Body
Trazodone has a half-life between five and 9 hours. This means it will take your body (on average) around seven hours to eliminate half of the drug. In a healthy adult, a single dosage of Trazodone can remain in the body for one to three days.
What are the side effects of trazodone?
Trazodone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- bad taste in mouth.
- changes in appetite or weight.
- weakness or tiredness.
Is it OK to take 100mg of trazodone for sleep?
Trazodone is most often prescribed at doses between 25mg to 100mg as a sleep aid. However, studies show lower dosages of trazodone are effective and may cause less daytime sleepiness and fewer side effects because the drug is short acting.
What are the long term side effects of trazodone?
What Are Side Effects Associated with Using Trazodone?
- blurred vision.
- dry mouth.
- headache or mild headache.
Does Trazodone affect memory?
Trazodone produced small but significant impairments of short-term memory, verbal learning, equilibrium, and arm muscle endurance across time points.