Most antipsychotics cause weight gain. The risk appears to be highest with olanzapine and clozapine. Weight increases rapidly in the initial period after starting antipsychotics. Patients continue to gain weight in the long term.
How much weight do you gain on olanzapine?
Results: Of the patients receiving olanzapine, 66.6% had a weight gain of 1–5 kg over a period of 4 weeks. The weight gain was not related to the dose of the drug or BMI.
Can you lose weight on olanzapine?
Results: Patients incurred an average weight loss of 2.7 +/- 0.7 kg (p = 0.001) after switching patients from olanzapine SOT to olanzapine ODT at 12 months. Peak weight loss was observed at 6 months; however, significant weight loss was achieved as early as 3 months.
Does olanzapine increase appetite?
We also found that 70.8% patients increased their appetite within the first 4 weeks of initial olanzapine treatment with a mean of 20.3 days to increase. Some patients even increased their appetite as early as the third day after olanzapine treatment.
Does olanzapine affect metabolism?
Olanzapine, which is a second-generation antipsychotic drug, can cause metabolic side effects, including hyperphagia, weight gain and acute hyperglycaemia.
How does Olanzapine make you feel?
These can include feeling very thirsty, needing to urinate often, having an increased appetite, or feeling weak. If you have these symptoms, check your fasting blood sugar level and call your doctor. For people with heart problems: Olanzapine can cause a sudden drop in blood pressure.
Who should not take olanzapine?
low levels of white blood cells. low levels of a type of white blood cell called neutrophils. suicidal thoughts. a type of movement disorder called parkinsonism.
Does olanzapine help anxiety?
Atypical antipsychotics such as quetiapine, aripiprazole, olanzapine, and risperidone have been shown to be helpful in addressing a range of anxiety and depressive symptoms in individuals with schizophrenia and schizoaffective disorders, and have since been used in the treatment of a range of mood and anxiety disorders …
What can replace olanzapine?
- Zyprexa (olanzapine) Prescription only. …
- 6 alternatives.
- Risperdal (risperidone) Prescription only. …
- Seroquel (quetiapine) Prescription only. …
- Abilify (aripiprazole) Prescription only. …
- Haldol (haloperidol) Prescription only. …
- Invega (paliperidone) Prescription only. …
- Clozaril (clozapine) Prescription only.
What is best antidepressant for weight loss?
A few antidepressants have had reports of causing weight loss: bupropion (Aplenzin, Forfivo, Wellbutrin); this has the most studies connecting it to weight loss. fluoxetine (Prozac); results vary though some people experience weight loss. duloxetine (Cymbalta); while results are unclear, some people report weight loss.
Does olanzapine work right away?
Peak blood levels are reached within six hours of taking a single dose of oral olanzapine. Effects are long lasting, so olanzapine should be dosed once a day; however, it may take several weeks of continued dosing before a reduction in symptoms is seen.
How do you avoid weight gain on antipsychotics?
Patients experiencing atypical antipsychotic-induced weight gain can use calorie reduction and dietary education programs, as well as pharmacologic treatment.
What are the side effects of olanzapine?
Olanzapine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dizziness, feeling unsteady, or having trouble keeping your balance.
- unusual behavior.
- difficulty falling asleep or staying asleep.
- difficulty walking.
What are the long term effects of olanzapine?
Long term (months or years) of elevated prolactin can lead to osteoporosis, or increased risk of bone fractures. Some people may develop muscle related side effects while taking olanzapine. The technical terms for these are “extrapyramidal symptoms” (EPS) and “tardive dyskinesia” (TD).
Is olanzapine habit forming?
Zyprexa has no habit-forming potential, but it is not recommended that you discontinue use of the drug before talking with your doctor, as withdrawal symptoms can occur.
Can you lose weight while taking antipsychotics?
Many people taking antipsychotics can lose some weight with simple changes to their diet and lifestyle. Losing even a small amount of weight can have important health benefits. Ongoing research is attempting to find ways to better manage or ideally avoid this problem.