Most antidepressants are selective serotonin reuptake inhibitor (SSRI). They boost the levels of serotonin in the brain. Bupropion, or Wellbutrin, is different. It is a norepinephrine-dopamine reuptake inhibitor (NDRI).
Is Wellbutrin an MAOI?
Compared to classical tricyclic antidepressants, Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine. In addition, Bupropion does not inhibit monoamine oxidase.
What class of drug is Wellbutrin?
WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines.
Is Wellbutrin a MOA?
Preclinical and clinical data demonstrate that bupropion acts via dual inhibition of norepinephrine and dopamine reuptake, which constitutes a novel mechanism of antidepressant action. As such, bupropion is associated with a unique clinical profile with efficacy comparable to that of other antidepressants.
Why was Wellbutrin discontinued?
The decision is based on an FDA study that found that the extended release (XL) form of bupropion — Budeprion XL — at the 300 milligram (mg) dose was not bioequivalent to brand-name Wellbutrin XL at the same dose, suggesting that it may not be as safe and effective.
What medications should not be taken with Wellbutrin?
Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not take bupropion to treat more than one condition at a time.
What is a good substitute for bupropion?
- Wellbutrin (bupropion) Prescription only. 60% of people say it’s worth it. …
- 10 alternatives.
- Buspar (buspirone) Prescription only. …
- Cymbalta (duloxetine) Prescription only. …
- Celexa (citalopram) Prescription only. …
- Zoloft (sertraline) Prescription only. …
- Remeron (mirtazapine) Prescription only. …
- Oleptro (trazodone) Prescription only.
How does Wellbutrin make you feel?
Shortly after beginning Wellbutrin, some people may have symptoms such as: anxiety. feeling restless. agitation.
Is Wellbutrin similar to Adderall?
Wellbutrin and Adderall belong to different drug classes. Wellbutrin is an aminoketone antidepressant and Adderall is an amphetamine.
Which is better Lexapro or Wellbutrin?
Wellbutrin (Bupropion) Improves mood and helps you relax. Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions.
What are the long term effects of taking Wellbutrin?
Rash, nausea, agitation, and migraine were the most frequently cited adverse events leading to discontinuation in the bupropion SR clinical trials. Bupropion SR is also well tolerated with long-term use.
Does Wellbutrin raise dopamine levels?
Bupropion is unique among antidepressants as an inhibitor of dopamine reuptake, leading to increased dopamine levels in the synapse. This has lead to its use as a smoking cessation therapy, the indication for which it is most commonly prescribed. Another unique feature of bupropion is its lack of serotonergic effects.
Does Wellbutrin give you energy?
On the other hand, bupropion does stand out among the antidepressants as having a positive effect on energy. When patients are up and active during the day, they are likely to sleep better at night.
Does Wellbutrin increase motivation?
In summary, bupropion can increase the motivation to work for food reinforcement, particularly in animals with poor baseline performance.
Why does Wellbutrin smell so bad?
An alternate explanation for the unpleasant odor is that the cysteine derivatizes into N-acetylcysteine (NAC), a variant of cysteine that has many possible health benefits, but a naturally sulfurous smell.
Is generic bupropion as good as Wellbutrin?
The U.S. Food and Drug Administration (FDA) finally has admitted that the generic of the popular antidepressant Wellbutrin XL is not as effective as GlaxoSmithKline’s original drug.